We don't know why, but being in space causes us to destroy our blood
Space isn't easy on humans. Some aspects are avoidable-the vacuum, of course, and the cold, as well as some of the radiation. Astronauts can also lose bone density, thanks to a lack of gravity. NASA has even created a fun acronym for the issues: RIDGE, which stands for space radiation, isolation and confinement, distance from Earth, gravity fields, and hostile and closed environments.
https://arstechnica.com/science/2022/01/we-dont-know-why-but-being-in-space-causes-us-to-destroy-our-blood/