Cas12a

Creator

Creator

Seonglae Cho

Created

Created

2025 Apr 13 23:28

Editor

Editor

Seonglae Cho

Edited

Edited

2025 Jul 10 21:16

Refs

Refs

Seamless gene editing

CRISPR-Cas12a can induce and track changes in a variety of immune system cells in response to gene editing and fine-tune sets of genes in different directions simultaneously.

New CRISPR tool enables more seamless gene editing — and improved disease modeling

Yale scientists have developed a CRISPR technology that can assess genetic interactions on a host of immunological responses to multiple diseases, including cancer.

https://news.yale.edu/2025/03/20/new-crispr-tool-enables-more-seamless-gene-editing-and-improved-disease-modeling

New CRISPR tool enables more seamless gene editing — and improved disease modeling

Simultaneous Editing

Multiplexed genome engineering by Cas12a and CRISPR arrays encoded on single transcripts

Nature Methods - A single transcript encoding Cas12a and an array of CRISPR RNAs enables multiplexed genome engineering, from multiple knockouts to transcriptional activation or repression to...

https://www.nature.com/articles/s41592-019-0508-6

Multiplexed genome engineering by Cas12a and CRISPR arrays encoded on single transcripts

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