python ast

config_keys = [k for k, v in globals().items() if not k.startswith(
    '_') and isinstance(v, (int, float, bool, str))]
# overrides from command line or config file
exec(open('configurator.py').read())
config = {k: globals()[k] for k in config_keys}  # will be useful for logging

comfigurator.py

import sys
from ast import literal_eval

for arg in sys.argv[1:]:
    if '=' not in arg:
        # assume it's the name of a config file
        assert not arg.startswith('--')
        config_file = arg
        print(f"Overriding config with {config_file}:")
        with open(config_file) as f:
            print(f.read())
        exec(open(config_file).read())
    else:
        # assume it's a --key=value argument
        assert arg.startswith('--')
        key, val = arg.split('=')
        key = key[2:]
        if key in globals():
            try:
                # attempt to eval it it (e.g. if bool, number, or etc)
                attempt = literal_eval(val)
            except (SyntaxError, ValueError):
                # if that goes wrong, just use the string
                attempt = val
            # ensure the types match ok
            assert type(attempt) == type(globals()[key])
            # cross fingers
            print(f"Overriding: {key} = {attempt}")
            globals()[key] = attempt
        else:
            raise ValueError(f"Unknown config key: {key}")