Seonglae ChoStarting point: Transcription Network. Early 2000s, Uri Alon, Ron Milo. Created and analyzed as a directed graph (Superfamily).
- Nodes = genes
- Edges = regulatory relationships (activation / repression)
In bacterial gene networks like E. coli, certain 3-node patterns repeat abnormally often: feed-forward loops. This led to the concept of "basic computational units of biological networks." Comparing motif profiles across networks → the claim that "networks also have evolutionary patterns." Superfamily. @Delay Circuit