Drosophila connectome

How to simulate via a sensory interface

(a) Retina mapping

• MuJoCo camera → downsample

• convert to photoreceptor neuron firing

(b) Olfaction (smell)

• No real chemical sensing so instead:
• an "odor scalar field"
• mapped to activation of a specific neuron group

(c) Touch

• contact force → mechanosensory neuron firing

• motor neuron firing → joint torque

• a specific neuron cluster → leg movement

hard-coded mappings are almost required

4) Calibration / tuning

• synaptic weight scaling

• global gain tuning

• noise injection

• homeostasis constraints

5) (almost certainly) some learning / fitting is involved

• RL fine-tuning

• parameter fitting

• or:
• behavior cloning (partially)

Network statistics of the whole-brain connectome of Drosophila

Nature - The network of the fly brain is highly recurrent and displays rich-club organization, with a large population (30%) of preferentially connected neurons.

https://www.nature.com/articles/s41586-024-07968-y

Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

Nature - Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

https://www.nature.com/articles/s41586-024-07974-0

The fly connectome reveals a path to the effectome

Nature - Analysis of the whole-brain fly connectome reveals high-dimensional dynamics supported by many small independent circuits, motivating a proposal for optogenetic perturbation to efficiently...

https://www.nature.com/articles/s41586-024-07982-0

Nature - Wiring diagram

Neurons in the brain are connected by synapses to form sophisticated circuits that drive complex behaviours such as social interaction and navigation. But to...

https://www.nature.com/nature/volumes/634/issues/8032

MANC

MANC connectome

With about 23,000 neurons, 10 million pre-synaptic sites, and 74 million post-synaptic densities, the male adult nerve cord (MANC) connectome is a densely reconstructed map of synaptic connections in

https://www.janelia.org/project-team/flyem/manc-connectome