Seonglae ChoA brain map that comprehensively represents the connections between neurons in the brain, essentially a brain circuit diagram.
Published in the Open Connectome Project
A unique personal property that differs even between twins
Connectomes
FlyWire
FlyWire
Since 2019, scientists and experienced proofreaders have utilized FlyWire to proofread AI segmentation of a
full fly brain (Dorkenwald et al., Zheng et al.). As of October 2024, the flagship FlyWire paper, Neuronal wiring diagram of
an adult brain, has been published in Nature, which includes 139,255 proofread neurons
(Dorkenwald et al.).
The companion papers include hierarchical annotation of all proofread neurons
(Schlegel et al.)
and a comprehensive cell type catalog of the visual system
(Matsliah, Yu et al.).
https://flywire.ai/
FlyWire
https://ngl.flywire.ai/
Virtual Fly Brain
Welcome to Virtual Fly Brain (VFB) - an interactive tool for neurobiologists to explore the detailed neuroanatomy, neuron connectivity and gene expression of Drosophila melanogaster. Our goal is to make it easier for researchers to find relevant anatomical information and reagents. We integrate the neuroanatomical and expression data from the published literature, as well as image datasets onto the same brain template, making it possible to run cross searches, find similar neurons and compare image data on our 3D Viewer.
https://www.virtualflybrain.org/
Open Connectome
Open Connectome
J. T. Vogelstein, E. Perlman, B. Falk, A. Baden, W. Gray Roncal, V. Chandrashekhar, F. Collman, S. Seshamani, J. L. Patsolic, K. Lillaney, M. Kazhdan, R. Hider, D. Pryor, J. Matelsky, T. Gion, P. Manavalan, B. Wester, M. Chevillet, E. T. Trautman, K. Khairy, E. Bridgeford, D. M. Kleissas, D.
https://neurodata.io/project/ocp/
The brain develops later than expected, remains stable longer, and ages in stages. Brain development can be divided into 5 stages based on age:
- 0–9 Synapses are overproduced, then pruned to keep only frequently used connections.→ Brain wiring construction phase.
- 9–32 Brain connections become progressively more efficient and organized. Adolescent changes continue into early 30s.→ Disproves the idea that "the brain is finished by age 20".
- 32–66 No major structural changes; plateau/stability phase. Intelligence and personality relatively stable. However, regions become increasingly specialized (modularized). Efficiency ↓, segregation ↑.
- 66–83 White matter begins to deteriorate → reduced connectivity. 'Early aging brain'. Modularity ↑.
- 83+ Overall network weakens, more reliance on specific regions. 'Late aging brain' relies on local processing.
4,216 people aged 0–90 were scanned using diffusion MRI to create Connectomes. 12 graph theory metrics (efficiency, modularity, centrality, etc.) were examined simultaneously, and these high-dimensional metrics were compressed using UMAP, then the points where the 'trajectory of connectivity structure changes with age' were identified.
www.nature.com
https://www.nature.com/articles/s41467-025-65974-8