Aging

Biological Age

• First, strength training. Myokines/exerkines secretion delays muscle and systemic aging

• Avoid overeating but maintain adequate protein intake and appropriate calorie consumption

• Taurine and NAD precursors (NMN, NR) proven to extend animal lifespan can support mitochondrial function

• Omega-3, alpha-lipoic acid, and Coenzyme Q10 protect against oxidative stress and support cardiovascular health

• Vitamins D and K2 are important for bone, muscle, and immune health

• Include leucine and BCAAs when consuming protein to prevent sarcopenia

• The Mediterranean diet is generally an excellent balanced diet plan

• Foods to avoid include excessive red meat, processed foods, and fructose

Making Cells Young

In the laboratory, cellular reprogramming can reverse epigenetic damage and reset cells to a "young" state. Can we do the same for entire organisms?

https://press.asimov.com/resources/making-cells-young

Why time seems to pass faster as we age - Inverted Passion

1/ I’ve been mega-obsessed with this feeling. A year as a 36-year-old seems so much shorter as compared to when I was a kid or even as a teen. It seems cosmically unfair – we have fewer years to live, and each year flies by faster. 2/ But, why is that happening? My tentative conclusion is that… Read More

https://invertedpassion.com/why-time-seems-to-pass-faster-as-we-age/

A Biochemist's View of Life's Origin Reframes Cancer and Aging | Quanta Magazine

All living cells power themselves by coaxing energetic electrons from one side of a membrane to the other. Membrane-based mechanisms for accomplishing this are, in a sense, as universal a feature of life as the genetic code.

https://www.quantamagazine.org/a-biochemists-view-of-lifes-origin-reframes-cancer-and-aging-20220808/

Real age versus biological age: the startups revealing how old we really are

t the end of last year, Jay Chan, a 30-year-old marine engineer, bought his mother a biological age test from Elysium, a New York-based biotech and health supplements start-up founded in 2014. The test was simple - it required only a saliva sample - and it helped that it was being offered for half off the usual $499 (£400) price.

https://www.theguardian.com/science/2022/jun/13/biological-age-startups-why

Reelin

A protein called Reelin keeps popping up in brains that resist aging and Alzheimer’s

Early in life, the protein Reelin helps assemble the brain. Later on, it appears to protect the organ from Alzheimer’s and other threats to memory and thinking.

https://www.npr.org/sections/shots-health-news/2024/07/29/g-s1-13519/alzheimers-protein-reelin-brain-aging-amyloid-tau-memory

Fight Aging!

The science of rejuvenation biotechnology. Advocacy for longer, healthier lives.

https://www.fightaging.org/

Human genetic variation-based targeting increases the probability of success, but mostly for rare diseases (small patient populations) → commercial success is difficult. Age-related diseases represent the largest market (TAM), but genetic targets and existing approaches barely work. Drug development mimicking interventions with proven multi-pathway effects, like exercise, is limited due to complexity, while targeting "obvious targets" such as amyloid, complement proteins, etc. has shown no clinical efficacy.

Where are all the trillion dollar biotechs? — lada nuzhna

Of the many trends people chase in biotech, the only one that proves sure and consistent is declining returns. Even after adjusting for inflation, the number of new drugs approved per $1 billion of R&D spending has halved approximately every nine years since 1950. Deloitte’s forecast R&a

https://www.ladanuzhna.xyz/writing/trillion-dollar-biotechs