Seonglae ChoAfter age 70, humans have a significantly higher risk of dying from chronic diseases, with our evolutionarily determined lifespan being around 70 years. Modern longevity often involves life extension through treating chronic diseases without artificial interventions. Recent technological approaches to slow aging include rapamycin and a protein called GDF11, but due to difficulties with human experimentation, many researchers are trying to apply these treatments to dogs as a more economical approach.
Immortal Notion
Immortal Foundation
The biggest reason I want immortality isn't just for the desire of influence or fear, but primarily out of Curiosity - Seonglae Cho
Semaglutide
Semaglutide could be used to slow down the process of aging
Ozempic weight loss: Jabs could slow ageing, researchers say
New studies suggest the weight loss drug could be used to treat a range of issues, including heart failure.
https://www.bbc.com/news/articles/ce81j919gdjo
The billion-dollar search for immortality
There's nothing noble about cheating death
https://unherd.com/2023/06/the-billion-dollar-search-for-immortality/
There's a Parasite That Triples Ants' Lifespans… And It Actually Sounds Pretty Great
Don't try this at home.
https://www.sciencealert.com/theres-a-parasite-that-triples-ants-lifespans-and-it-actually-sounds-pretty-great
Anti-aging molecules safely reset mouse cells to youthful states
One of the especially promising therapies to appear in the realm of anti-aging research involves a set of molecules known as Yamanaka factors, which scientists have deployed to rejuvenate aging cells, trigger muscle regeneration and tackle glaucoma. New research at the Salk Institute has sought to...
https://newatlas.com/health-wellbeing/anti-aging-molecules-reset-cells-youthful-states/
A plant that 'cannot die' reveals its genetic secret
The longest-lived leaves in the plant kingdom can be found only in the harsh, hyperarid desert that crosses the boundary between southern Angola and northern Namibia. A desert is not, of course, the most hospitable place for living things to grow, let alone leafy greens, but the Namib Desert - the world's oldest, with parts receiving less than 2 inches of precipitation a year - is where Welwitschia calls home.
https://indianexpress.com/article/technology/science/welwitschia-plant-that-cannot-die-genetic-secret-7434368/?utm_source=tldrnewsletter
Scientists Rewind The Clock of Human Skin Cells to Make Them Act 30 Years Younger
It's not quite the mythical fountain of youth but it is, perhaps, a start: Scientists have managed to engineer human skin cells to reverse 30 years of aging, resetting them to a much more youthful state in terms of certain molecular measurements.
https://www.sciencealert.com/scientists-rewind-the-age-of-human-skin-cells-back-30-years
Scientists Say They Found the Genes That Makes Immortal Jellyfish Immortal
The secret of immortality may be contained within a jellyfish smaller than a human fingernail, so scientists have spent the last several decades trying to unlock the secrets of Turritopsis dohrnii, more commonly called the immortal jellyfish.
https://futurism.com/the-byte/scientists-genes-immortal-jellyfish
Tardigrade protein
Scientists Put Tardigrade Proteins Into Human Cells. Here's What Happened.
This is how we develop superpowers.
https://www.sciencealert.com/scientists-put-tardigrade-proteins-into-human-cells-heres-what-happened
Longevity Research
- Sirtuin-based treatments: NAD⁺ precursors (NMN, NR, etc.) supplementation shows some benefits for healthspan in animal studies, but has minimal effects on actual lifespan extension.
- Cellular reprogramming: Periodic expression of OSKM factors has shown improvement in aging markers and 10-20% lifespan extension in mice (2023 AAV delivery method experiment), but remains in pre-clinical stages before human application.
A primer on the current state of longevity research
4k words, 19 minutes reading time
https://www.owlposting.com/p/some-questions-and-answers-i-had
