Onion model

Overall theory

• Oxidative stress

• Hyperfunction theory

12 Main Causes of Aging:

1. Genomic Instability

2. Telomere Attrition

3. Epigenetic Alterations

4. Loss of Proteostasis

5. Mitochondrial Dysfunction

6. Cellular Senescence

7. Stem Cell Exhaustion

8. Deregulated Nutrient Sensing

9. Altered Intercellular Communication

10. Disabled Macroautophagy

11. Chronic Inflammation (Inflammaging)

12. Accumulation of Cellular Damage

6 Emerging Factors:

1. Microbiome Alterations

2. Circadian Rhythm Disruption

3. Immune System Dysregulation (Immunosenescence)

4. Metabolic Waste Accumulation (e.g., Lipofuscin)

5. Glycation and Advanced Glycation End-Products (AGEs)

6. Caloric Overload and Nutrient Excess

Are these 18 things all that's killing you?

Here is a list of the known reasons for aging, combining 12 of the best-supported with 6 additional emerging factors that are under investigation (and some ideas about what you can do to mitigate each):

https://domofutu.substack.com/p/these-18-things